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KMID : 1149220050130010103
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Korean Journal of Oriental Medical Prescription
2005 Volume.13 No. 1 p.103 ~ p.121
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Effect of the neuroprotetion and anti-Alzheimer’s disease in CT99-induced Neuro 2A cells by Ikgiansintang water extract
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Hwang Yeon-Kyu
Lee So-Yeon
Yoon Hyeon-Deok
Shin Wo-Cheol
Park Chang-Gook
Park Chi-Sang
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Abstract
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Alzheimer’s disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. It has been widely believed that Aβ peptide devided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that n99 may be an important factor causing neurotoxicity in AD. Mouse Neuro 2A cells expressed with CT99 exhibited remarkable apoptotic cell damage. We invesgated the protective effects of Ikgiansintang water extract(IGA). Findings from our experiment have shown that IGA inhibits the activities of CT99, which has neurotoxicities and apoptotic activities in cell line. In addition treatment of IGA(50 ㎍/ml for 24 hours) partially prevented CT99-induced cytotoxicity in Neuro 2A cells. As the result of this study, In IGA group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuro 2A cells by n99 expression is promoted. Base on these findings, IGA may be beneficial for the treatment of AD.
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KEYWORD
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CT99, Ikgiansintang, Alzheimer’s disease
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